复方苦芩对细小病毒感染犬血液T细胞亚群和细胞因子的影响

doi:10.11843/j.issn.0366-6964.2017.02.021

Abstract

Abstract:

In order to study the effect of compound Kuqin on T cell subsets and cytokines of blood in canines with canine parvovirus, we established the canine parvovirus model, and separate 120 canines into 6 groups, like blank control group, model group, positive medicine group, compound Kuqin high dose group, middle dose group, low dose group, with 20 canines in each group. We set the time point that 6 hours after the virus was inoculated as 0 d, and collect the blood sampling from the canine saphenous vein at the day 0, day 7, day 14, day 21, day 28, and day 35. T lymphocyte subsets were detected by flow cytometry, and the cytokines IL-2, IL-4, IFN-γ were detected by kit. The result showed that, compared with the model group, compound Kuqin can promote the secretion of IL-2, IL-4, IFN-γ, and increase the percentage of CD3⁺, CD3⁺CD4⁺T cells in peripheral blood, and decrease the percentage of CD3⁺CD8⁺T cells. In conclusion, compound Kuqin can regulate canines’ immune function and improve the ability of antiviral after they were infected by canine parvovirus.

CLC Number:

S853.74

LIU Juan, WU Qiu-yue, QIU Hong. Effect of Compound Kuqin on T Cell Subsets and Cytokines of Blood in Canines with Canine Parvovirus[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(2): 369-376.

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Effect of Compound Kuqin on T Cell Subsets and Cytokines of Blood in Canines with Canine Parvovirus

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